The dual action of glioma-derived exosomes on neuronal activity: synchronization and disruption of synchrony

Abstract Seizures represent a frequent symptom in gliomas and significantly impact patient morbidity and quality of life. Although the pathogenesis of tumor-related seizures is not fully understood, accumulating evidence indicates a key role of the peritumoral microenvironment. Brain cancer cells in...

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Main Authors: Renza Spelat, Nie Jihua, Cesar Adolfo Sánchez Triviño, Simone Pifferi, Diletta Pozzi, Matteo Manzati, Simone Mortal, Irene Schiavo, Federica Spada, Melania Eva Zanchetta, Tamara Ius, Ivana Manini, Irene Giulia Rolle, Pietro Parisse, Ana P. Millán, Ginestra Bianconi, Fabrizia Cesca, Michele Giugliano, Anna Menini, Daniela Cesselli, Miran Skrap, Vincent Torre
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05144-6