Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae

Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae

Abstract Background Cysteine protease inhibitors of Brugia malayi have been ascribed to be involved in parasite development as well as to immunomodulate the host’s immune response. In Onchocerca volvulus, Onchocystatin has been shown to induce partial protection in the mouse diffusion chamber vaccin...

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Bibliographic Details
Main Authors: Sridhar Arumugam, Bin Zhan, David Abraham, Danielle Ward, Sara Lustigman, Thomas R Klei
Format: Article
Language:English
Published: BMC 2014-01-01
Series:Parasites & Vectors
Subjects:
Brugia malayi
Cysteine protease inhibitors
Filariasis
Vaccination
Worm migration
Immunomodulation
Online Access:https://doi.org/10.1186/1756-3305-7-43

Internet

https://doi.org/10.1186/1756-3305-7-43

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