Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya

Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya

Abstract Communications between immune cells are essential to ensure appropriate coordination of their activities. Here, we observed the infiltration of activated macrophages into the joint-footpads of chikungunya virus (CHIKV)-infected animals. Large numbers of CD64+MHCII+ and CD64+MHCII- macrophag...

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Bibliographic Details
Main Authors: Fok-Moon Lum, Yi-Hao Chan, Teck-Hui Teo, Etienne Becht, Siti Naqiah Amrun, Karen WW Teng, Siddesh V Hartimath, Nicholas KW Yeo, Wearn-Xin Yee, Nicholas Ang, Anthony M Torres-Ruesta, Siew-Wai Fong, Julian L Goggi, Evan W Newell, Laurent Renia, Guillaume Carissimo, Lisa FP Ng
Format: Article
Language:English
Published: Springer Nature 2024-02-01
Series:EMBO Molecular Medicine
Subjects:
Chikungunya
Immune Crosstalk
Immunopathogenesis
GM-CSF
Online Access:https://doi.org/10.1038/s44321-024-00028-y

Internet

https://doi.org/10.1038/s44321-024-00028-y

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