Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca<sup>2+</sup> Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca<sup>2+</sup> Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Novel multitarget-directed ligands <b>BIGI 4a-d</b> and <b>BIGI 5a-d</b> were designed and synthesized with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel antagonism,...

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Bibliographic Details
Main Authors: Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
Biginelli reaction
multitarget-directed ligands
calcium channel antagonism
Nrf2
Online Access:https://www.mdpi.com/1420-3049/28/1/71

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https://www.mdpi.com/1420-3049/28/1/71

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