Novel Use of PLGA Microspheres to Create an Animal Model of Glaucoma with Progressive Neuroretinal Degeneration

Novel Use of PLGA Microspheres to Create an Animal Model of Glaucoma with Progressive Neuroretinal Degeneration

Progressive degeneration of neuroretinal tissue with maintained elevated intraocular pressure (IOP) to simulate chronic glaucoma was produced by intracameral injections of poly (lactic-co-glycolic) acid (PLGA) microspheres (Ms) in rat eyes. The right eye of 39 rats received different sizes of PLGA-M...

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Bibliographic Details
Main Authors: David Garcia-Herranz, Maria Jesus Rodrigo, Manuel Subias, Teresa Martinez-Rincon, Silvia Mendez-Martinez, Irene Bravo-Osuna, Aina Bonet, Jesus Ruberte, Julian Garcia-Feijoo, Luis Pablo, Elena Garcia-Martin, Rocío Herrero-Vanrell
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
PLGA microspheres
intraocular pressure
glaucoma animal model
intracameral injection
optic nerve
neurodegeneration
Online Access:https://www.mdpi.com/1999-4923/13/2/237

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https://www.mdpi.com/1999-4923/13/2/237

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