Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids

Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids

Abstract In this research, a 3D brain organoid model is developed to study POLG‐related encephalopathy, a mitochondrial disease stemming from POLG mutations. Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utilized to generate cortical organoids, which exhibited...

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Bibliographic Details
Main Authors: Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth John Sullivan, Charalampos Tzoulis, Laurence A. Bindoff, Kristina Xiao Liang
Format: Article
Language:English
Published: Wiley 2024-05-01
Series:Advanced Science
Subjects:
cortical organoids
iPSC
mitochondrial function
neuron
POLG
Online Access:https://doi.org/10.1002/advs.202307136

Internet

https://doi.org/10.1002/advs.202307136

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