Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

Abstract Background Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and fibro...

Full description

Bibliographic Details
Main Authors: Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad, Edith Hochhauser
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cardiovascular Diabetology
Subjects:
Caloric restriction
Cardiomyopathy
Diabetes mellitus
SIRT1
PGC-1α
Online Access:http://link.springer.com/article/10.1186/s12933-018-0754-4

Internet

http://link.springer.com/article/10.1186/s12933-018-0754-4

Similar Items