FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells

FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells

Male ageing is always accompanied by decreased fertility. The forkhead O (FOXO) transcription factor FOXO4 is reported to be highly expressed in senescent cells. Upon activation, it binds p53 in the nucleus, preventing senescent cell apoptosis and maintaining senescent cells in situ. Leydig cells pl...

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Detalhes bibliográficos
Main Authors: Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Liu
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2024-10-01
Colecção:Experimental Gerontology
Assuntos:
FOXO4-DRI
Spermatogenesis
Senescence
Leydig cell
SASP (senescence-associated secretory phenotype)
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0531556524001645

Internet

http://www.sciencedirect.com/science/article/pii/S0531556524001645

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