FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells
Male ageing is always accompanied by decreased fertility. The forkhead O (FOXO) transcription factor FOXO4 is reported to be highly expressed in senescent cells. Upon activation, it binds p53 in the nucleus, preventing senescent cell apoptosis and maintaining senescent cells in situ. Leydig cells pl...
| Hauptverfasser: | , , , , , , , , , , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
2024-10-01
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| Schriftenreihe: | Experimental Gerontology |
| Schlagworte: | |
| Online Zugang: | http://www.sciencedirect.com/science/article/pii/S0531556524001645 |