Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

Abstract Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell‐free circulating tumor DNA (ctDNA) contains tumor‐specific chromosomal rearrangements that may be interrogated in blood plasma. We evaluated serial monitoring of ctDNA for ear...

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Bibliographic Details
Main Authors: Eleonor Olsson, Christof Winter, Anthony George, Yilun Chen, Jillian Howlin, Man‐Hung Eric Tang, Malin Dahlgren, Ralph Schulz, Dorthe Grabau, Danielle van Westen, Mårten Fernö, Christian Ingvar, Carsten Rose, Pär‐Ola Bendahl, Lisa Rydén, Åke Borg, Sofia K Gruvberger‐Saal, Helena Jernström, Lao H Saal
Format: Article
Language:English
Published: Springer Nature 2015-05-01
Series:EMBO Molecular Medicine
Subjects:
breast carcinoma
circulating tumor DNA
early detection
liquid biopsy
metastasis
Online Access:https://doi.org/10.15252/emmm.201404913

Internet

https://doi.org/10.15252/emmm.201404913

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