The Formation of RNA Pre-Polymers in the Presence of Different Prebiotic Mineral Surfaces Studied by Molecular Dynamics Simulations

The Formation of RNA Pre-Polymers in the Presence of Different Prebiotic Mineral Surfaces Studied by Molecular Dynamics Simulations

We used all-atom Molecular Dynamics (MD) computer simulations to study the formation of pre-polymers between the four nucleotides in RNA (AMP, UMP, CMP, GMP) in the presence of different substrates that could have been present in a prebiotic environment. Pre-polymers are <inline-formula><ma...

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Bibliographic Details
Main Authors: Alix Dujardin, Sebastian Himbert, Ralph Pudritz, Maikel C. Rheinstädter
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Life
Subjects:
origins of life
non-enzymatic RNA polymerization
prebiotic mineral surfaces
molecular dynamics simulations
hydrogen-bonded RNA pre-polymers
Online Access:https://www.mdpi.com/2075-1729/13/1/112

Internet

https://www.mdpi.com/2075-1729/13/1/112

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