Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis

Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis

Abstract Background The pathogenesis of osteoarthritis (OA) involves the progressive degradation of articular cartilage. Exosomes derived from mesenchymal stem cells (MSC-EXOs) have been shown to mitigate joint pathological injury by attenuating cartilage destruction. Optimization the yield and ther...

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Bibliographic Details
Main Authors: Jiangyi Wu, Jinhui Wu, Wei Xiang, Yunquan Gong, Daibo Feng, Shunzheng Fang, Yaran Wu, Zheng Liu, Yang Li, Ran Chen, Xiaoqi Zhang, Bingfei Li, Lifeng Chen, Runze Jin, Song Li, Bin Zhang, Tongyi Zhang, Lin Yin, Yizhao Zhou, Shu Huang, Ningning Liu, Hao Xu, Jiqin Lian, Yongqian Wang, Siru Zhou, Zhenhong Ni
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Journal of Nanobiotechnology
Subjects:
Osteoarthritis
Exosomes
TNF-α precondition
Mesenchymal stem cells
Chondrocytes
Online Access:https://doi.org/10.1186/s12951-024-02795-9

Internet

https://doi.org/10.1186/s12951-024-02795-9

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