Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure

Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure

Abstract Background Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such as brain plasticity and memory, and altered PNN structures have been fou...

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Bibliographic Details
Main Authors: Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Véronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali, Denis Vivien
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Biology
Subjects:
Tissue-type plasminogen activator
Plasminogen
Parvalbumin interneurons
Perineuronal nets
Aggrecan
Online Access:https://doi.org/10.1186/s12915-022-01419-8

Internet

https://doi.org/10.1186/s12915-022-01419-8

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