Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL

Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL

Abstract Background Tetrandrine, a bisbenzylisoquinoline (BBI) alkaloid extracted from Stephania tetrandra (S. Moore), and is widely used in several diseases such as tuberculosis, hyperglycemia, malaria, and tumors. Tetrandrine was recently shown to prevent bone loss in ovariectomized mice. However,...

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Bibliographic Details
Main Authors: Jiarui Li, Xiang Li, Shengji Zhou, Yuxin Wang, Yang Lu, Quan Wang, Fengchao Zhao
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Medicine
Subjects:
Tetrandrine
TRAIL
RANKL
Osteoclastogenesis
OVX
Online Access:https://doi.org/10.1186/s10020-022-00568-4

Internet

https://doi.org/10.1186/s10020-022-00568-4

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