Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients

Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients

Abstract The aim of this study was to evaluate the effect of UGT1A1 polymorphisms on Raltegravir (RAL) and its metabolite RAL-glucuronide trough plasma concentrations ([RAL]plasma and [RAL-glu]plasma) and on the metabolic ratio (MR): [RAL-glu]plasma/[RAL]plasma. UGT1A1 genotyping was performed on 96...

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Bibliographic Details
Main Authors: Leïla Belkhir, Carole Seguin-Devaux, Laure Elens, Caroline Pauly, Nicolas Gengler, Serge Schneider, Jean Ruelle, Vincent Haufroid, Bernard Vandercam
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25803-z

Internet

https://doi.org/10.1038/s41598-018-25803-z

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