ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process

ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process

Abstract Background Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with regards to the integrin-related mechanosensitive signaling pathway. We have previously reported that the silencing of ex...

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Bibliographic Details
Main Authors: David Gagné, Yannick D. Benoit, Jean-François Groulx, Pierre H. Vachon, Jean-François Beaulieu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Molecular and Cell Biology
Subjects:
ILK
IPP complex
Integrin
α5β1
RhoA
Fibronectin
Online Access:http://link.springer.com/article/10.1186/s12860-020-00259-0

Internet

http://link.springer.com/article/10.1186/s12860-020-00259-0

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