Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200...

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Bibliographic Details
Main Authors: Lukas Vrba, Taylor J Jensen, James C Garbe, Ronald L Heimark, Anne E Cress, Sally Dickinson, Martha R Stampfer, Bernard W Futscher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2805718?pdf=render

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http://europepmc.org/articles/PMC2805718?pdf=render

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