Identification of a Novel Osteogenetic Oligodeoxynucleotide (osteoDN) That Promotes Osteoblast Differentiation in a TLR9-Independent Manner

Identification of a Novel Osteogenetic Oligodeoxynucleotide (osteoDN) That Promotes Osteoblast Differentiation in a TLR9-Independent Manner

Dysfunction of bone-forming cells, osteoblasts, is one of the causes of osteoporosis. Accumulating evidence has indicated that oligodeoxynucleotides (ODNs) designed from genome sequences have the potential to regulate osteogenic cell fate. Such osteogenetic ODNs (osteoDNs) targeting and activating o...

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Bibliographic Details
Main Authors: Yuma Nihashi, Mana Miyoshi, Koji Umezawa, Takeshi Shimosato, Tomohide Takaya
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Nanomaterials
Subjects:
osteogenetic oligodeoxynucleotide (osteoDN)
osteoblast
bone differentiation
calcification
mineralization
Toll-like receptor 9 (TLR9)
Online Access:https://www.mdpi.com/2079-4991/12/10/1680

Internet

https://www.mdpi.com/2079-4991/12/10/1680

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