PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia

PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia

Abstract Background Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors. Programmed Death Ligand -1 (CD-274) is one of the immune checkpoint ligands that do not only cause the immune escape of can...

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Bibliographic Details
Main Authors: Mojdeh Soltani, Mustafa Ghanadian, Behrooz Ghezelbash, Abolfazl Shokouhi, Andrey A. Zamyatnin, Alexandr V. Bazhin, Mazdak Ganjalikhani-Hakemi
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Cancer
Subjects:
Acute myeloid leukemia
AML
Fatty acid oxidation
Immunometabolism
Pentose phosphate pathway
Programmed death ligand-1
Online Access:https://doi.org/10.1186/s12885-023-10947-7

Internet

https://doi.org/10.1186/s12885-023-10947-7

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