An evolutionary conserved detoxification system for membrane lipid-derived peroxyl radicals in Gram-negative bacteria.

An evolutionary conserved detoxification system for membrane lipid-derived peroxyl radicals in Gram-negative bacteria.

How double-membraned Gram-negative bacteria overcome lipid peroxidation is virtually unknown. Bactericidal antibiotics and superoxide ion stress stimulate the transcription of the Burkholderia cenocepacia bcnA gene that encodes a secreted lipocalin. bcnA gene orthologs are conserved in bacteria and...

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Bibliographic Details
Main Authors: Marwa Naguib, Nicolás Feldman, Paulina Zarodkiewicz, Holly Shropshire, Christina Biamis, Omar M El-Halfawy, Julia McCain, Clément Dezanet, Jean-Luc Décout, Yin Chen, Gonzalo Cosa, Miguel A Valvano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001610

Internet

https://doi.org/10.1371/journal.pbio.3001610

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