Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily internalises and digests large volumes of spent photoreceptor outer segments. Impaired cargo handling and processing i...

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Bibliographic Details
Main Authors: Eloise Keeling, Andrew J. Lotery, David A. Tumbarello, J. Arjuna Ratnayaka
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Cells
Subjects:
Retinal Pigment Epithelium (RPE)
endosomes
phagosomes
lysosomes
autophagy
RPE cultures
Age-related Macular Degeneration (AMD)
Online Access:http://www.mdpi.com/2073-4409/7/2/16

Internet

http://www.mdpi.com/2073-4409/7/2/16

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