A new mechanism for a familiar mutation – bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

A new mechanism for a familiar mutation – bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

Abstract Background The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with a large influence on milk composition phenotypes. Since first described over 15 years ag...

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Bibliographic Details
Main Authors: Tania Fink, Thomas J. Lopdell, Kathryn Tiplady, Renee Handley, Thomas J. J. Johnson, Richard J. Spelman, Stephen R. Davis, Russell G. Snell, Mathew D. Littlejohn
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Genomics
Subjects:
Cattle
RNA
Transcriptomics
Milk
RNA splicing
QTL
Online Access:http://link.springer.com/article/10.1186/s12864-020-07004-z

Internet

http://link.springer.com/article/10.1186/s12864-020-07004-z

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