Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain

Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain

The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four α-helices. ATAD2 functions as a co-activator of the androgen and estrogen receptors as well as the MYC and E2F transcription factors. ATAD2 also functions during DNA...

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Bibliographic Details
Main Authors: Chiara M. Evans, Margaret Phillips, Kiera L. Malone, Marco Tonelli, Gabriel Cornilescu, Claudia Cornilescu, Simon J. Holton, Mátyás Gorjánácz, Liping Wang, Samuel Carlson, Jamie C. Gay, Jay C. Nix, Borries Demeler, John L. Markley, Karen C. Glass
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
ATAD2 bromodomain
acetylated histones
post-translational modifications
X-ray crystallography
nuclear magnetic resonance
isothermal titration calorimetry
Online Access:https://www.mdpi.com/1422-0067/22/17/9128

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https://www.mdpi.com/1422-0067/22/17/9128

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