Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA

Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA

Gene therapies, including genome editing, RNAi, anti-sense technology and chemical DNA editing are becoming major methods for the treatment of genetic disorders. Techniques like CRISPR-Cas9, zinc finger nuclease (ZFN) and transcription activator-like effector-based nuclease (TALEN) are a few such en...

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Bibliographic Details
Main Authors: Siddhant Sethi, Shigetaka Nakamura, Kenzo Fujimoto
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
deamination
C to U transition
cyanovinylcarbazole
photo-cross-linking
genome editing
Online Access:http://www.mdpi.com/1420-3049/23/4/828

Internet

http://www.mdpi.com/1420-3049/23/4/828

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