Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal Cancer

Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal Cancer

Locally advanced rectal cancer (LARC) remains a medical challenge. Reliable biomarkers to predict which patients will significantly respond to neoadjuvant chemoradiotherapy (nCRT) have not been identified. We evaluated baseline genomic and transcriptomic features to detect differences that may help...

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Bibliographic Details
Main Authors: Juan M. Sendoya, Soledad Iseas, Mariana Coraglio, Mariano Golubicki, Juan Robbio, Ruben Salanova, Mirta Kujaruk, Vanesa Mikolaitis, Mariana Rizzolo, Gonzalo Ruiz, Ana Cabanne, Ubaldo Gualdrini, Guillermo Mendez, Stella Hirmas, Cecilia Rotondaro, Julieta Viglino, Martín Eleta, Elmer Fernandez, Martín Abba, Osvaldo Podhajcer, Enrique Roca, Andrea S Llera
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
rectal cancer
immune response
gene expression
neoadjuvant chemoradiotherapy
biomarker
Online Access:https://www.mdpi.com/2072-6694/12/8/2227

Internet

https://www.mdpi.com/2072-6694/12/8/2227

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