Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function

Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function

Ewing sarcoma (EwS) is an aggressive pediatric cancer of bone and soft tissues characterized by scant T cell infiltration and predominance of immunosuppressive myeloid cells. Given the important roles of extracellular vesicles (EVs) in cancer-host crosstalk, we hypothesized that EVs secreted by EwS...

Full description

Bibliographic Details
Main Authors: Hendrik Gassmann, Kira Schneider, Valentina Evdokimova, Peter Ruzanov, Sebastian J. Schober, Busheng Xue, Kristina von Heyking, Melanie Thiede, Guenther H. S. Richter, Michael W. Pfaffl, Elfriede Noessner, Lincoln D. Stein, Poul H. Sorensen, Stefan E. G. Burdach, Uwe Thiel
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
myeloid cells
dendritic cells
Ewing sarcoma
extracellular vesicles
inflammation
immunosuppression
Online Access:https://www.mdpi.com/2073-4409/10/8/2081

Internet

https://www.mdpi.com/2073-4409/10/8/2081

Similar Items