Quantitation of certolizumab pegol by validated liquid chromatography methods

Quantitation of certolizumab pegol by validated liquid chromatography methods

Abstract Certolizumab pegol (CZP) is a Fab’ fragment of the humanized antibody with anti-TNF-α activity that is indicated as therapy for Crohn’s disease and rheumatoid arthritis. Using a BioSep-SEC-S3000 column (300 x 4.6 mm i.d., 5 µm particle size), a size exclusion liquid chromatography (SEC) met...

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Bibliographic Details
Main Authors: Clóvis Dervil Appratto Cardoso Júnior, Bruna Xavier, Rafaela Ferreira Perobelli Dumoncel, Francielle Santos da Silva, Sérgio Luiz Dalmora
Format: Article
Language:English
Published: Universidade de São Paulo 2023-11-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Certolizumab pegol
Monoclonal antibody
Size exclusion liquid chromatography
Reversed-phase liquid chromatography
Validation.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100422&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100422&tlng=en

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