Development of an Improved 3D in vitro Intestinal Model to Perform Permeability Studies of Paracellular Compounds

The small intestine is the primary site of drug absorption following oral administration, making paramount the proper monitoring of the absorption process. In vitro tools to predict intestinal absorption are particularly important in preclinical drug development since they are less laborious and cos...

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Bibliographic Details
Main Authors: Maria Helena Macedo, Elena Martínez, Cristina C. Barrias, Bruno Sarmento
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.524018/full