Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity

Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity

Summary: Cell polarity is essential for the architecture and function of numerous epithelial tissues. Here, we show that apical restriction of planar cell polarity (PCP) components is necessary for the maintenance of epithelial integrity. Using the mammalian pancreas as a model, we find that compone...

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Bibliographic Details
Main Authors: Lydie Flasse, Siham Yennek, Cédric Cortijo, Irene Seijo Barandiaran, Marine R.-C. Kraus, Anne Grapin-Botton
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
planar polarity
pancreas architecture
development
apical
PCP
VANGL
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306306

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http://www.sciencedirect.com/science/article/pii/S2211124720306306

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