Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties

Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties

Abstract Oncogenic activation of receptor tyrosine kinases (RTKs) such as MET is associated with cancer initiation and progression. We designed and synthesized a new series of quinazoline derivatives bearing 1,2,3-triazole moiety as targeted anticancer agents. The MET inhibitory effect of synthesize...

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Bibliographic Details
Main Authors: Motahareh Mortazavi, Masoomeh Eskandari, Fatemeh Moosavi, Tahereh Damghani, Mehdi Khoshneviszadeh, Somayeh Pirhadi, Luciano Saso, Najmeh Edraki, Omidreza Firuzi
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41283-2

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https://doi.org/10.1038/s41598-023-41283-2

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