Effects of gestational inflammation on age-related cognitive decline and hippocampal Gdnf-GFRα1 levels in F1 and F2 generations of CD-1 Mice

Effects of gestational inflammation on age-related cognitive decline and hippocampal Gdnf-GFRα1 levels in F1 and F2 generations of CD-1 Mice

Abstract Background It has been reported that age-associated cognitive decline (AACD) accelerated by maternal lipopolysaccharide (LPS) insult during late pregnancy can be transmitted to the second generation in a sex-specificity manner. In turn, recent studies indicated that glial cell line‐derived...

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Bibliographic Details
Main Authors: Bao-Ling Luo, Zhe-Zhe Zhang, Jing Chen, Xue Liu, Yue-Ming Zhang, Qi-Gang Yang, Gui-Hai Chen
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Neuroscience
Subjects:
Ageing
Learning and memory
GDNF-GFRα1
Inflammation
Intergenerational transmission
Mice
Online Access:https://doi.org/10.1186/s12868-023-00793-5

Internet

https://doi.org/10.1186/s12868-023-00793-5

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