Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer

Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer

Abstract Background First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activity regulates YAP and TAZ final effectors. In response to upstream s...

Full description

Bibliographic Details
Main Authors: Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon, Marcello Maugeri-Saccà
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Hippo pathway
YAP/TAZ
Gastrointestinal tumors
Precancerous lesions
Chronic inflammation
Fibrosis
Online Access:https://doi.org/10.1186/s12967-024-05027-8

Internet

https://doi.org/10.1186/s12967-024-05027-8

Similar Items