Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma

Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (<i>VHL</i>) is the truncal driver mutation of most cases of ccRCC. Cancer cells are metabolically reprogrammed and excrete modified nucl...

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Bibliographic Details
Main Authors: Daniel A. Mohl, Simon Lagies, Kyra Zodel, Matthias Zumkeller, Asin Peighambari, Athina Ganner, Dietmar A. Plattner, Elke Neumann-Haefelin, Mojca Adlesic, Ian J. Frew, Bernd Kammerer
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
biomarkers
biomarker discovery
ccRCC
kidney cancer
metabolomics
mass spectrometry
Online Access:https://www.mdpi.com/2073-4409/12/8/1102

Internet

https://www.mdpi.com/2073-4409/12/8/1102

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