MET Receptor Tyrosine Kinase Inhibition Reduces Interferon-Gamma (IFN-γ)-Stimulated PD-L1 Expression through the STAT3 Pathway in Melanoma Cells

MET Receptor Tyrosine Kinase Inhibition Reduces Interferon-Gamma (IFN-γ)-Stimulated PD-L1 Expression through the STAT3 Pathway in Melanoma Cells

Melanoma is the leading cause of death from cutaneous malignancy. While targeted therapy and immunotherapy with checkpoint inhibitors have significantly decreased the mortality rate of this disease, advanced melanoma remains a therapeutic challenge. Here, we confirmed that interferon-gamma (IFN-γ)-i...

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Bibliographic Details
Main Authors: Kyu Young Song, Yong Hwan Han, Heidi Roehrich, Mary E. Brown, Carlos Torres-Cabala, Alessio Giubellino
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
MET
PD-L1
melanoma
immunotherapy
tyrosine kinase inhibitors
STAT3
Online Access:https://www.mdpi.com/2072-6694/15/13/3408

Internet

https://www.mdpi.com/2072-6694/15/13/3408

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