ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants

ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants

Abstract Background Our laboratory identified ADGRL4/ELTD1, an orphan GPCR belonging to the adhesion GPCR (aGPCR) family, as a novel regulator of angiogenesis and a potential anti-cancer therapeutic target. Little is known about how ADGRL4/ELTD1 (and aGPCRs in general) function, a problem compounded...

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Bibliographic Details
Main Authors: David M. Favara, Alison H. Banham, Adrian L. Harris
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Evolutionary Biology
Subjects:
ADGRL4
ELTD1
Adhesion GPCR evolution
Online Access:http://link.springer.com/article/10.1186/s12862-019-1445-9

Internet

http://link.springer.com/article/10.1186/s12862-019-1445-9

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