Leishmania guyanensis suppressed inducible nitric oxide synthase provoked by its viral endosymbiont

Leishmania guyanensis suppressed inducible nitric oxide synthase provoked by its viral endosymbiont

Inducible nitric oxide synthase (iNOS) is essential to the production of nitric oxide (NO), an efficient effector molecule against intracellular human pathogens such as Leishmania protozoan parasites. Some strains of Leishmania are known to bear a viral endosymbiont termed Leishmania RNA virus 1 (LR...

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Bibliographic Details
Main Authors: Dmitry Kopelyanskiy, Chantal Desponds, Florence Prevel, Matteo Rossi, Romain Migliorini, Tiia Snäkä, Remzi Onur Eren, Stéphanie Claudinot, Lon-Fye Lye, Manolis Pasparakis, Stephen M. Beverley, Nicolas Fasel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmania
Leishmania RNA virus 1 (LRV1)
type I Interferons
nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)
inducible nitric oxide synthase (iNOS)
tumor necrosis factor-alpha-induced protein 3 (A20)
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.944819/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.944819/full

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