Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling

Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling

Abstract Neuronal atrophy is a common pathological feature occurred in aging and neurodegenerative diseases. A variety of abnormalities including motor protein malfunction and mitochondrial dysfunction contribute to the loss of neuronal architecture; however, less is known about the intracellular si...

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Bibliographic Details
Main Authors: Zhi-Dong Liu, Su Zhang, Jian-Jin Hao, Tao-Rong Xie, Jian-Sheng Kang
Format: Article
Language:English
Published: Oxford University Press 2016-08-01
Series:Protein & Cell
Subjects:
RAS-RAF-MEK pathway
atrophy
dynein intermediate chain
mitochondria
hippocampal neuron
autophagy
Online Access:http://link.springer.com/article/10.1007/s13238-016-0301-6

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http://link.springer.com/article/10.1007/s13238-016-0301-6

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