Reactivities of a Prostanoid EP2 Agonist, Omidenepag, Are Useful for Distinguishing between 3D Spheroids of Human Orbital Fibroblasts without or with Graves’ Orbitopathy

Reactivities of a Prostanoid EP2 Agonist, Omidenepag, Are Useful for Distinguishing between 3D Spheroids of Human Orbital Fibroblasts without or with Graves’ Orbitopathy

Background. To obtain new insights into the activation of the thyroid-stimulating hormone (TSH) and insulin-like growth factor 1 (IGF-1) receptors in human orbital fibroblasts (n-HOFs), the effects of the prostanoid EP2 agonist, omidenepag (OMD), and a rho-associated coiled-coil-containing protein k...

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Bibliographic Details
Main Authors: Yosuke Ida, Hanae Ichioka, Masato Furuhashi, Fumihito Hikage, Megumi Watanabe, Araya Umetsu, Hiroshi Ohguro
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
prostanoid EP2 agonist
ROCK inhibitor
three-dimension (3D) cell culture
Graves’ orbitopathy
IGF-1
orbital fibroblast
Online Access:https://www.mdpi.com/2073-4409/10/11/3196

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https://www.mdpi.com/2073-4409/10/11/3196

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