Maternal inflammation induces spatial learning and memory impairment in the F1 and F2 generations of mice via sex-specific epigenetic mechanisms

Maternal inflammation induces spatial learning and memory impairment in the F1 and F2 generations of mice via sex-specific epigenetic mechanisms

Mounting evidence indicates that histone modifications are involved in aging-associated cognitive decline (AACD) and can be transmitted to offspring over multiple generations under conditions of stress. Here, we investigated the effects of maternal sub-chronic inflammation caused by lipopolysacchari...

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Bibliographic Details
Main Authors: Zhe-Zhe Zhang, Jing Chen, Bao-Ling Luo, Ming-Zhu Ni, Xue Liu, Li-Ping Zeng, Qi-Gang Yang, Fang Wang, Gui-Hai Chen
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Brain Research Bulletin
Subjects:
Aging
Epigenetic modification
Intergenerational transmission
Learning and memory
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022001873

Internet

http://www.sciencedirect.com/science/article/pii/S0361923022001873

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