miR-542-3p Attenuates Bone Loss and Marrow Adiposity Following Methotrexate Treatment by Targeting sFRP-1 and Smurf2

miR-542-3p Attenuates Bone Loss and Marrow Adiposity Following Methotrexate Treatment by Targeting sFRP-1 and Smurf2

Intensive methotrexate (MTX) treatment for childhood malignancies decreases osteogenesis but increases adipogenesis from the bone marrow stromal cells (BMSCs), resulting in bone loss and bone marrow adiposity. However, the underlying mechanisms are unclear. While microRNAs (miRNAs) have emerged as b...

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Bibliographic Details
Main Authors: Ya-Li Zhang, Liang Liu, Yu-Wen Su, Cory J. Xian
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
methotrexate
miRNA-542-3p
bone formation
marrow adiposity
Online Access:https://www.mdpi.com/1422-0067/22/20/10988

Internet

https://www.mdpi.com/1422-0067/22/20/10988

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