Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting

Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting

Chemotherapy-induced nausea and vomiting (CINV) is a complex pathophysiological condition and consists of two phases. The conventional CINV neurotransmitter hypothesis suggests that the immediate phase is mainly due to release of serotonin (5-HT) from the enterochromaffin cells in the gastrointestin...

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Bibliographic Details
Main Author: Nissar A. Darmani
Format: Article
Language:English
Published: MDPI AG 2010-09-01
Series:Pharmaceuticals
Subjects:
cannabinoids
acute
delayed
emesis
CB1 receptor
endocannabinoids
antiemetics
chemotherapy
Online Access:http://www.mdpi.com/1424-8247/3/9/2930/

Internet

http://www.mdpi.com/1424-8247/3/9/2930/

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