Synthesis and Evaluation of Some New Aza-B-homocholestane Derivatives as Anticancer Agents

Synthesis and Evaluation of Some New Aza-B-homocholestane Derivatives as Anticancer Agents

Using analogues of some marine steroidal oximes as precursors, a series of aza-B-homocholestane derivatives possessing different substituted groups at the 3-position of the steroidal nucleus were synthesized. Their biological activity against cancer cell proliferation was determined with multiple c...

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Bibliographic Details
Main Authors: Yanmin Huang, Jianguo Cui, Sijing Chen, Qifu Lin, Huacan Song, Chunfang Gan, Bin Su, Aimin Zhou
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Marine Drugs
Subjects:
aza-B-homo-cholestane derivatives
anticancer agents
cytotoxicity
3D multicellular spheroids screening
apoptosis
Online Access:http://www.mdpi.com/1660-3397/12/4/1715

Internet

http://www.mdpi.com/1660-3397/12/4/1715

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