Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways

Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways

Abstract Background Itaconate, a crucial immunometabolite, plays a critical role in linking immune and metabolic functions to influence host defense and inflammation. Due to its polar structure, the esterified cell-permeable derivatives of itaconate are being developed to provide therapeutic opportu...

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Bibliographic Details
Main Authors: Young Jae Kim, Eun-Jin Park, Sang-Hee Lee, Prashanta Silwal, Jin Kyung Kim, Jeong Seong Yang, Jake Whang, Jichan Jang, Jin-Man Kim, Eun-Kyeong Jo
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
Dimethyl itaconate
Mycobacterium tuberculosis
Nontuberculous mycobacteria
Innate immunity
Autophagy
Host-directed therapeutics
Online Access:https://doi.org/10.1186/s13578-023-00992-x

Internet

https://doi.org/10.1186/s13578-023-00992-x

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