Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism

Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism

In vertebrate species, fertility is controlled by gonadotropin-releasing hormone (GnRH) neurons. GnRH cells arise outside the central nervous system, in the developing olfactory pit, and migrate along olfactory/vomeronasal/terminal nerve axons into the forebrain during embryonic development. Congeni...

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Bibliographic Details
Main Authors: Ludovica Cotellessa, Federica Marelli, Paolo Duminuco, Michela Adamo, Georgios E. Papadakis, Lucia Bartoloni, Naoko Sato, Mariarosaria Lang-Muritano, Amineh Troendle, Waljit S. Dhillo, Annamaria Morelli, Giulia Guarnieri, Nelly Pitteloud, Luca Persani, Marco Bonomi, Paolo Giacobini, Valeria Vezzoli
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-03-01
Series:JCI Insight
Subjects:
Development
Genetics
Online Access:https://doi.org/10.1172/jci.insight.161998

Internet

https://doi.org/10.1172/jci.insight.161998

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