Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming—A New Mechanism for SCLC Chemoresistance Boosted by Nicotine

Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming—A New Mechanism for SCLC Chemoresistance Boosted by Nicotine

Up to 60% of patients with small cell lung cancer (SCLC) continue to smoke, which is associated with worse clinical outcomes. Platinum-based chemotherapies, in combination with topoisomerase inhibitors, are first-line therapies for SCLC, with rapid chemoresistance as a major barrier. We provided evi...

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Bibliographic Details
Main Authors: Yuzhi Wang, Tengfei Bian, Lina Song, Yunhan Jiang, Zhiguang Huo, Ramzi G. Salloum, Graham W. Warren, Frederic J. Kaye, Naomi Fujioka, Lingtao Jin, Chengguo Xing
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
SCLC
nicotine
cotinine
platinum-based therapy
DNA damage
chemoresistance
Online Access:https://www.mdpi.com/2072-6694/14/9/2272

Internet

https://www.mdpi.com/2072-6694/14/9/2272

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