N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

Summary: CircRNAs play multiple roles in a variety of cellular processes. We found that Circ-CDYL is highly enriched in early HCC plasma exosomes. Moreover, EpCAM+ HCC cells and exosomes had significant Circ-CDYL levels. We postulated that Circ-CDYL-enriched and EpCAM-positive exosomes would functio...

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Bibliographic Details
Main Authors: Yanping Wei, Jingbo Fu, Hailing Zhang, Yan Ling, Xuewu Tang, Shuowu Liu, Miao Yu, Fuyan Liu, Guokun Zhuang, Haihua Qian, Kecheng Zhang, Pinhua Yang, Xinwei Yang, Qi Yang, Shennian Ge, Baohua Zhang, Yexiong Tan, Liang Li, Hongyang Wang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Biological sciences
Genetics
Molecular biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223020990

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223020990

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