Deep neural network for prediction and control of permeability decline in single pass tangential flow ultrafiltration in continuous processing of monoclonal antibodies

Deep neural network for prediction and control of permeability decline in single pass tangential flow ultrafiltration in continuous processing of monoclonal antibodies

Single-pass tangential flow filtration (SPTFF) is a crucial technology enabling the continuous manufacturing of monoclonal antibodies (mAbs). By significantly increasing the membrane area utilized in the process, SPTFF allows the mAb process stream to be concentrated up to the desired final target i...

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Bibliographic Details
Main Authors: Naveen G. Jesubalan, Garima Thakur, Anurag S. Rathore
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Chemical Engineering
Subjects:
SPTFF
NWP
deep neural network
continuous processing
bioprocessing
Online Access:https://www.frontiersin.org/articles/10.3389/fceng.2023.1182817/full

Internet

https://www.frontiersin.org/articles/10.3389/fceng.2023.1182817/full

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