Evaluation of NS4A, NS4B, NS5 and 3′UTR Genetic Determinants of WNV Lineage 1 Virulence in Birds and Mammals

Evaluation of NS4A, NS4B, NS5 and 3′UTR Genetic Determinants of WNV Lineage 1 Virulence in Birds and Mammals

West Nile virus (WNV) is amplified in an enzootic cycle involving birds as amplifying hosts. Because they do not develop high levels of viremia, humans and horses are considered to be dead-end hosts. Mosquitoes, especially from the <i>Culex</i> genus, are vectors responsible for transmis...

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Bibliographic Details
Main Authors: Lise Fiacre, Steeve Lowenski, Céline Bahuon, Marine Dumarest, Bénédicte Lambrecht, Maha Dridi, Emmanuel Albina, Jennifer Richardson, Stéphan Zientara, Miguel-Ángel Jiménez-Clavero, Nathalie Pardigon, Gaëlle Gonzalez, Sylvie Lecollinet
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Viruses
Subjects:
West Nile virus
molecular determinants
virulence
reverse genetics
Online Access:https://www.mdpi.com/1999-4915/15/5/1094

Internet

https://www.mdpi.com/1999-4915/15/5/1094

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