The Protective Effects of a Synthetic Geranyl Acetophenone in a Cellular Model of TNF-α-Induced Pulmonary Epithelial Barrier Dysfunction

The Protective Effects of a Synthetic Geranyl Acetophenone in a Cellular Model of TNF-α-Induced Pulmonary Epithelial Barrier Dysfunction

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Alveolar epithelial barrier dysfunction contributes to lung edema and can lead to acute lung injury (ALI). The features include increased epithelial permeability, upregulation of inflammatory mediators and downregulation of junctional complex molecules; these changes are often induced by inflammatio...

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Bibliographic Details
Main Authors: Tee Yee Sim, Hanis Hazeera Harith, Chau Ling Tham, Nur Fariesha Md Hashim, Khozirah Shaari, Mohd Roslan Sulaiman, Daud Ahmad Israf
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
acetophenone
acute lung injury
inflammation
alveolar epithelial cells
barrier function
barrier integrity junctional
complex molecules
Online Access:http://www.mdpi.com/1420-3049/23/6/1355

Internet

http://www.mdpi.com/1420-3049/23/6/1355

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