Establishment and immune phenotyping of patient-derived glioblastoma models in humanized mice

Establishment and immune phenotyping of patient-derived glioblastoma models in humanized mice

Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor diagnosed in adults. Preclinical immunocompetent mouse tumor models generated using mouse tumor cells play a pivotal role in testing the therapeutic efficacy of emerging immune-based therapies for GBMs. However, the c...

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Bibliographic Details
Main Authors: Longsha Liu, Thijs A. van Schaik, Kok-Siong Chen, Filippo Rossignoli, Paulo Borges, Vladimir Vrbanac, Hiroaki Wakimoto, Khalid Shah
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
hGBM
GBM - multiforme
humanized mice
BLT humanized mice
flow cytometry
multiplex immunofluorescence staining
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324618/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324618/full

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